Christian Wolf, Ph.D.

Chemistry Professor
Director Medicinal Chemistry Shared Resource Center
Georgetown University
Department of Chemistry
37th and O Streets, NW
Washington, DC 20057, USA
Phone: +1 202 687 3468
Fax: +1 202 687 6209
Email:
Website:

EDUCATION
Ph.D. Organic Chemistry, University of Hamburg, Germany, December 1995

Dissertation Title: “Synthesis, Enantioseparation and Investigation of the Conformational Stability of Axially Chiral Biphenyls” Advisor: Professor Wilfried A. König
Diploma Chemistry, University of Hamburg, Germany, February 1993
B.S. Chemistry, University of Hamburg, Germany, September 1990

APPOINTMENTS
Director, Medicinal Chemistry Shared Resource Center, GU, Washington, DC August 2018 - present
Full Professor, Georgetown University, Chemistry Department, Washington, DC August 2011 - present
Associate Professor, Georgetown University, Chemistry Department, Washington, DC August 2006 - 2011
Assistant Professor, Georgetown University, Chemistry Department, Washington, DC August 2000 - July 2006
Senior Scientist, Chemical Development, R&D, SmithKline Beecham Pharmaceuticals, King of Prussia, PA December 1997 - July 2000
Alexander von Humboldt Feodor Lynen Postdoctoral Fellow, University of Illinois, Chemistry Department, Urbana-Champaign, IL. Advisor: Professor William H. Pirkle February 1996 – October 1997
Visiting Scholar at the University of Aix-Marseille III, Marseille, France July - August 1994, March - April 1995
Visiting Scholar at the University of Reading, Reading, UK April - June 1991

HONORS AND AWARDS

Distinguished Georgetown University Investigator, 2016
President’s Award for Distinguished Scholars-Teachers, 2015
Georgetown University Patent Awards, 2011, 2013, 2015, 2017
National Academy of Inventors Fellow, 2014
NSF CAREER Award, 2004-2009
TLTSI Award, Teaching, Learning, and Technology Summer Institute, 2003
Junior Faculty Research Fellowship, Georgetown University, 2003
Gold Impact Award, SmithKline Beecham, Pharmaceuticals, 2000
Silver Impact Award, SmithKline Beecham, Pharmaceuticals, 1998
Feodor Lynen Fellowship, Alexander von Humboldt Foundation, 1996-1997
Ph.D. Fellowship, German Chemical Industry, 1993-1995
Erasmus Fellowship, European Union, 1991

RESEARCH INTERESTS
Synthetic Methodology

Catalytic Asymmetric Synthesis

Catalyst Design (Wolf Bisoxazolidines etc.)

Green Chemistry

Organofluorine Synthesis

C-F Bond Functionalization

Ynamide Reactions
Chiral Recognition and Chemosensing Stereoselective

UV, Fluorescence and CD Sensing Methods

High-Throughput Asymmetric Reaction Screening Methodology

NMR Spectroscopy with Chiral Solvating Agents
Dynamic Stereochemistry of Chiral Compounds

Racemization, Diastereomerization and Atropisomerization Processes

Chiral Amplification and Asymmetric Transformation of the 1st and 2nd Kind
Transition Metal Catalysis

Cross-Coupling of Aryl Halides with Alkynes, Boronic Acids, Siloxanes, Grignard Reagents,
Organozinc Compounds and Stannanes Applications of Palladium Phosphinous Acid and Chlorophosphine Complexes
Medicinal Chemistry

Sensing of Biomarkers

Drug Discovery (Cancer, Parkinson, Alzheimer etc.)
Chiral Chromatography, Dynamic Chromatography

DGC, DHPLC, DSFC, Stopped Flow Methods
 

CURRENT COLLABORATIONS
Industrial
Chris Welch, Welch Innovation LLC, Cranbury, NJ, USA;

Chirality Projects
Leo Joyce, Ed Sherer, Merck, Rahway, NJ, USA;

Pharmaceutical Sciences

Justin Dragna, Enantiosense, Austin, TX, USA;

High-Throughput Chirality Sensing Commercialization

Academic

Andrea Mazzanti, University of Bologna, Italy;

Dynamic NMR Spectroscopy, Dynamic Stereochemistry, Chiral Amplification

Eric Anslyn, University of Texas, TX, USA;

Optical Sensing Method Development

Steve Byers, Aykut Uren, Rebecca Riggins, Georgetown University, Oncology Department, Washington, DC, USA;

Cancer Treatments

Charbel Moussa, Georgetown University, Department of Neurology, Washington, DC, USA;

Alzheimer and Parkinson Diseases
 

TEACHING
Graduate Courses
Synthesis (Chem 502)
Stereochemistry of Chiral Compounds (Chem 570)
Career Perspectives for Ph.D. Chemists (Elective Graduate Course)

Undergraduate Courses
Organic Chemistry Lecture I (Chem 115)
Organic Chemistry Lecture II (Chem 116)
Organic Chemistry Laboratory I (Chem 117)
Organic Chemistry Laboratory II (Chem 118)
Organic Chemistry Lecture II for Majors (Chem 120)
Synthetic Methods (Chem 228)

PROFESSIONAL AND EDITORIAL BOARD MEMBERSHIPS
American Chemical Society
Alexander von Humboldt Association
Editorial Board Member of the Journal Chirality
National Academy of Inventors
Cofounder of Enantiosense, LLC