SCIENTIFIC JOURNALS

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177)  Catalytic Asymmetric Allylic Alkylation with Arylfluoroacetonitriles
Sripada, A.; Wolf, C.
J. Org. Chem. 2022, 87, doi.org/10.1021/acs.joc.2c01414.

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176)  Dynamic Covalent Optical Chirality Sensing with a Sterically Encumbered Aminoborane
De los Santos, Z. A.; Lynch, C. C.; Wolf, C.
Chem. Eur. J. 2022, ASAP.

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175)  Selective Csp^3-F Bond Functionalization with Lithium Iodide
Balaraman, K.; Kyriazakos, S.; Palmer, R.; Thanzeel, F. Y.; Wolf, C.
Synthesis 2022, ASAP.

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174)  Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice
Liu, X.; Balaraman, K.; Lynch, C. C.; Hebron, M.; Shah, P. K.; Hu, S.; Stevenson, M.; Wolf, C.; Moussa, C.
Int. J. Mol. Sci. 2022, 23, 8131.

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173)  Chemodivergent Csp3-F Bond Functionalization and Cross-Electrophile Alkyl-Alkyl Coupling with Alkyl Fluorides
Balaraman, K.; Wolf, C.
Science Adv. 2022, 8, eabn7819.

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172)  Selective Chiroptical Sensing of D/L-Cysteine Mixtures
Kariapper, F. S.; Thanzeel, F. Y.; Zandi, L. S.; Wolf, C.
Org. Biomol. Chem. 2022, 20, 3056-3060.

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171)  Unified Sensing of the Concentration and Enantiomeric Composition of Chiral Compounds with an Achiral Probe
Sripada, A.; Thanzeel. F. Y.; Wolf, C.
Chem. 2022, 8, 1734-1749.

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170)  Accelerated Asymmetric Reaction Screening with Optical Assays
Hassan, D. S.; Kariapper, F. S.; Lynch, C. C.; Wolf, C.
Synthesis 2022, 54, 2527-2538.

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169)  Optical Deciphering of Multinary Chiral Compound Mixtures Through Organic Reaction Based Chemometric Chirality Sensing
Hassan, D. S.; Wolf, C.
Nat. Comm. 2021, 12, 6451.

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168)  Palladium and Nickel Catalyzed Suzuki Cross-Coupling with Alkyl Fluorides
Balaraman, K.; Wolf, C.
Org. Lett. 2021, 23, 8994-8999.

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167)  Chiroptical Switching and Quantitative Chirality Sensing with (Pseudo)halogenated Quinones
Formen, J. S. S. K.; Wolf, C.
Angew. Chem. Int. Ed. 2021, 60, 27031-27038.

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166)  Enantioseparation and Racemization of a-Aryl-a-Fluoroacetonitriles
Steber, S. E.; Pham, A. N. D. L.; Nelson, E.; Wolf, C.
Chirality 2021, 33, 891-898.

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165)  Novel Ubiquitin Specific Protease-13 Inhibitors May Alleviate Neurodegenerative Pathology
Liu, X.; Balaraman, K.; Lynch, C. C.; Hebron, M.; Wolf, C.; Moussa, C.
Metabolites 2021, 11, 622.

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164)  Rapid Organocatalytic Chirality Analysis of Amines, Amino Acids, Alcohols, Amino Alcohols and Diols with Achiral Iso(thio)cyanate Probes
Nelson, E.; Formen, J. S. S. K.; Wolf, C.
Chem. Sci. 2021, 12, 8784-8790.

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163)  Chemoselective Bioconjugation Based on Modular Click Chemistry with 4-Halocoumarins and Aryl Sulfonates
Thanzeel, F. Y.; Wolf, C.
RSC Adv. 2021, 11, 18960-18965.

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162)  Chiroptical Sensing of Amino Acids, Amines, Amino Alcohols, Alcohols and Terpenes with π-Extended Acyclic Cucurbiturils
Hassan, D. S.; De los Santos, Z. A.; Brady, K. G.; Murkli, S.; Isaacs, L.; Wolf, C.
Org. Biomol. Chem. 2021, 19, 4248-4253.

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161)  Asymmetric Synthesis with Ynamides: Unique Reaction Control, Chemical Diversity and Applications
Lynch, C. C.; Sripada, A.; Wolf, C.
Chem. Soc. Rev. 2020, 49, 8543-8583.

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160)  Chiroptical Sensing of Homocysteine
Thanzeel, F. Y.; Zandi, L. S.; Wolf, C.
Org. Biomol. Chem. 2020, 18, 8629-8632.

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159)  Ninhydrin Revisited: Quantitative Chirality Recognition of Amines and Amino Alcohols Based on Nondestructive Dynamic Covalent Chemistry
Pilicer, S. L.; Wolf, C.
J. Org. Chem. 2020, 85, 11560-11565.

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158)  Quantitative Chirality and Concentration Sensing of Alcohols, Diols, Hydroxy Acids, Amines and Amino Alcohols using Chlorophosphite Sensors in a Relay Assay
Thanzeel, F, Y.; Balaraman, K.; Wolf, C.
Angew. Chem. Int. Ed. 2020, 59, 21382-21386.

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157)  Discoidin Domain Receptor 1 is a Therapeutic Target for Neurodegenerative Diseases
Fowler, A. J.; Hebron, M.; Balaraman, K.; Shi, W.; Missner, A. A.; Greenzaid, J. D.; Chiu, T. L.; Ullman, C.; Weatherdon, E.; Duka, V.; Torres-Yaghi, Y.; Pagan, F. L.; Liu, X.; Ressom, H.; Ahn, J.; Wolf, C.; Moussa, C.
Hum. Mol. Genet. 2020, 29, 2882-2898.

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156)  High Throughput Determination of Enantiopurity by Microplate Circular Dichroism
Pilicer, S. L.; Dragna, J. M.; Garland, A. Welch, C. J.; Anslyn, E. V.; Wolf, C.
J. Org. Chem. 2020, 85, 10858-10864.

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155)  Catalytic Asymmetric Allylic Amination with Isatins Sulfonamides, Imides, Amines, and N-Heterocycles
Lynch, C. C.; Balaraman, K.; Wolf, C.
Org. Lett. 2020, 22, 3180-3184.

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154)  Optical Terpene and Terpenoid Sensing: Chiral Recognition, Determination of Enantiomeric Composition and Total Concentration Analysis with Late Transition Metal Complexes
De los Santos, Z. A.; Wolf, C.
J. Am. Chem. Soc. 2020, 142, 4121-4125.

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153)  Stereochemical Analysis of Chiral Amines, Diamines and Amino Alcohols: Practical Chiroptical Sensing Based on Dynamic Covalent Chemistry
Hassan, D. S.; Thanzeel, F. Y.; Wolf, C.
Chirality 2020, 32, 457-463.

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152)  Tandem Use of Optical Sensing and Machine Learning for the Determination of Absolute Configuration, Enantiomeric and Diastereomeric Ratios, and Concentration of Chiral Samples
De los Santos, Z. A.; MacAvaney, S.; Russell, K.; Wolf, C.
Angew. Chem. Int. Ed. 2020, 59, 2440-2448.

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151)  2-tert-Butyl-1,1,3,3-tetramethylguanidine
Balaraman, K.; Wolf, C.
e-EROS 2020.

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150)  Quantitative Chiroptical Sensing of Free Amino acids, Biothiols, Amines and Amino Alcohols with an Aryl Fluoride Probe
Thanzeel, F. Y.; Sripada, A.; Wolf, C.
J. Am. Chem. Soc. 2019, 141, 16382-16387.

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149)  Streamlined Asymmetric Reaction Development: A Case Study with Isatins
Thanzeel, F, Y.; Balaraman, K.; Wolf, C.
Chem. Eur. J. 2019, 25, 11020-11025.

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148)  Predictive Chirality Sensing via Schiff Base Formation
Pilicer, S. L.; Mancinelli, M.; Mazzanti, A.; Wolf, C.
Org. Biomol. Chem. 2019, 17, 6699-6705.

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147)  Chiroptical Sensing of Unprotected Amino Acids, Hydroxy acids, Amino Alcohols, Amines and Carboxylic Acids with Metal Salts
Lynch, C. C.; De los Santos, Z. A.; Wolf, C.
Chem. Commun. 2019, 55, 6297-6300.

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146)  Asymmetric Reaction Screening with a Click Chemistry Sensor
Thanzeel, F. Y. Balaraman, K.; Wolf, C.
Synform 2019, A88-A92.

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145)  Optical Chirality Sensing with a Stereodynamic Aluminum Biphenolate Probe
De los Santos, Z. A.; Joyce, L. A.; Sherer, E. C.; Welch, C. J.; Wolf, C.
J. Org. Chem. 2019, 84, 4639-4645.

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144)  Catalytic Asymmetric Mannich Reaction of α-Fluoronitriles with Ketimines: Enantioselective and Diastereodivergent Construction of Vicinal Tetrasubstituted Stereocenters
Ding, R.; De los Santos, Z. A.; Wolf, C.
ACS Catal. 2019, 9, 2169-2176.

143)  Catalytic Enantioselective Ynamide Additions to Isatins: Concise Access to Oxindole Alkaloids
Moskowitz, M.; Wolf, C.
Angew. Chem. Int. Ed. 2019, 58, 3402-3406.

142)   Enantioselective Sensing of Carboxylic Acids with a Bis(urea)oligo(phenylene)ethynylene Foldamer
De los Santos, Z. A.; Yusin, G.; Wolf, C.
Tetrahedron 2019, 75, 1504-1509.

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141)  Optical Chirality Sensing with an Auxiliary‐Free Earth‐Abundant Cobalt Probe
De los Santos, Z. A.; Lynch, C. C.; Wolf, C.
Angew. Chem. Int. Ed. 2019, 58. 1198-1202.

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140)  Click Chemistry Enables Quantitative Chiroptical Sensing of Chiral Compounds in Protic Media and Complex Mixtures
Thanzeel, F. Y. Balaraman, K.; Wolf, C.
Nat. Comm. 2018, 9, 5323.
Selected by the editors at Nature Communications as Editors’ Highlight.

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139)  Organocatalytic Decarboxylative Cyanomethylation of Difluoromethyl and Trifluoromethyl Ketones
Balaraman, K.; Moskowitz, M.; Wolf, C.
Adv. Synth. Catal. 2018, 360, 4705-4709.

 

138)  Optical Analysis of Reaction Yield and Enantiomeric Excess. A New Paradigm Ready for Prime Time
Herrera, B. T.; Pilicer, S. L.; Anslyn, E. V.; Joyce, L. A.; Wolf, C.
J. Am. Chem. Soc. 2018, 140, 10385-10401.
Featured in JACS Spotlight J. Am. Chem. Soc. 2018, 140, 10627-10628.

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137)  Organocatalytic Stereoselective Synthesis of Fluorinated 3,3'-Linked Bisoxindoles
Moskowitz, M.; Balaraman, K.; Wolf, C.
J. Org. Chem. 2018, 83, 1661-1666.

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136)     Organocatalytic Asymmetric Synthesis of a-Oxetanyl and α-Azetidinyl Tertiary Alkyl Fluorides and Chlorides
Ding, R.; Wolf, C.
Org. Lett. 2018, 20, 892-895.

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135)  Stereoselective Synthesis of 3,3’-Bisindolines by Organocatalytic Michael Additions of Fluorooxindole Enolates to Isatylidene Malononitriles in Aqueous Solution
Balaraman, K.; Ding, R.; Wolf, C.
Adv. Synth. Catal. 2017, 359, 4165-4169.
Selected as VIP.

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134)  Chirality Sensing with Stereodynamic Copper(I) Complexes
De los Santos, Z. A.; Legaux, N. M.; Wolf, C.
Chirality 2017, 29, 663-669.

133)   Substrate-Specific Amino Acid Sensing Using a Molecular D/L-Cysteine Probe for Comprehensive Stereochemical Analysis in Aqueous Solution
Thanzeel, F. Y.; Wolf, C.
Angew. Chem. Int. Ed. 2017, 56, 7276-7281.

132)   Organocatalytic Insertion of Isatins into Aryl Difluoronitromethyl Ketones
Ding, R.; Bakhshi, P. R.; Wolf, C.
J. Org. Chem. 2017, 82, 1273-1278.

131)   Catalytic Enantioselective and Diastereoselective Allylic Alkylation with Fluoroenolates: Efficient Access to C3-Fluorinated and All-Carbon Quaternary Oxindoles
Balaraman, K.; Wolf, C.
Angew. Chem. Int. Ed. 2017, 56, 1390-1395.
Featured in Synfacts 2017, 13, 383.

130)  Biomimetic Chirality Sensing with Pyridoxal-5’-phosphate
Pilicer, S. L.; Bakhshi, P. R.; Bentley, K. W.; Wolf, C.
J. Am. Chem. Soc. 2017, 139, 1758-1761.

129)  Chiroptical Asymmetric Reaction Screening via Multicomponent Self-Assembly
De los Santos, Z. A.; Wolf, C.
J. Am. Chem. Soc. 2016, 138, 13517-13520.
Featured in Chemical & Engineering News 2016, 94, issue 42, p.8, and in JACS Spotlight J. Am. Chem. Soc. 2016, 138, 14507-14508.

128)  Chirality Imprinting and Direct Asymmetric Reaction Screening Using a Stereodynamic Brønsted/Lewis Acid Receptor
Bentley, K. W.; Proano, D.; Wolf, C.
Nat. Commun. 2016, 7, 12539.

127)  Enantiomerization Kinetics of 2,2’-Disubstituted Biphenyls: A Dynamic Chiral HPLC Investigation
Moskowitz, M. Xu, H.; Wolf, C.
IJC 2016, 56, 1052-1056. (Invited article)

126)  Detrifluoroacetylative Generation of Halogenated Enolates: Practical Access to Perhalogenated Ketones and Alkenes
Balaraman, K.; Moskowitz, M.; Liu, Y.; Wolf, C.
Synthesis 2016, 48, 2376-2384. (Invited article)
Featured as a Highlight in Current Synthetic Organic Chemistry in Synfacts 2016, 1033.

125)  Miniature High-Throughput Chemosensing of Yield, Ee and Absolute Configuration From Crude Reaction Mixtures
Bentley, K. W.; Zhang, P.; Wolf, C.
Science Adv. 2016, 2, e1501162.

124)    Catalytic Insertion of Aldehydes into Dihalonitroacetophenones via Sequential Bond Scission-Aldol Reaction-Acyl Transfer
Ding, R.; Wolf, C.
Chem. Commun. 2016, 52, 3576-3579.

123)    Efficient Access to Multifunctional Trifluoromethyl Alcohols through Base-Free Catalytic Asymmetric C−C Bond Formation with Terminal Ynamides
Cook, A. M.; Wolf, C.
Angew. Chem. Int. Ed. 2016, 55, 2929-2933.
Featured as a Highlight in Current Synthetic Organic Chemistry in Synfacts 2016, 485.

122)    Antenna Biphenols: Development of Extended Wavelength Chiroptical Reporters
Bentley, K. W.; Joyce, L. A.; Sherer, E. C.; Sheng, H.; Wolf, C.; Welch, C. J.
J. Org. Chem. 2016, 81, 1185-1191.

121)    Quantitative Chirality Sensing of Amines and Amino Alcohols via Schiff Base Formation with a Stereodynamic UV/CD Probe
De los Santos, Z. A.; Ding, R.; Wolf, C.
Org. Biomol. Chem. 2016, 14, 1934-1939.

120)    Computational and DNMR Analysis of the Conformational Isomers and Stereodynamics of Secondary 2,2’-Bisanilides
Mazzanti, A.; Chiarucci, M.; Prati, L.; Bentley, K. W.; Wolf, C.
J. Org. Chem. 2016, 81, 89-99.

119)    Chirality Sensing with Stereodynamic Biphenolate Zinc Complexes
Bentley, K. W.; De los Santos, Z. A.; Wolf, C.
Chirality 2015, 27, 700-707.

118)    Terminal Ynamides: Synthesis, Coupling Reactions, and Additions to Common Electrophiles (invited article)
Cook, A. M.; Wolf, C.
Tetrahedron Lett. 2015, 56, 2377-2392.

117)    Comprehensive Chirality Sensing: Development of Stereodynamic Probes with a Dual (Chir)optical Response
Bentley, K. W., Wolf, C.
J. Org. Chem. 2014, 79, 6517-6531.

116)     Computational and DNMR Investigation of the Isomerism and Stereodynamics of the 2,2’-Binaphthalene-1,1’-diol Scaffold
Mazzanti, A.; Chiarucci, M.; Bentley, K. W.; Wolf, C.
J. Org. Chem. 2014, 79, 3725-3730.

115)    Copper(I) Catalyzed Nucleophilic Addition of Ynamides to Acyl Chlorides and Activated N-Heterocycles
Zhang, P.; Cook, A. M.; Liu, Y.; Wolf, C.
J. Org. Chem. 2014, 79, 4167-4173.

114)    Circular Dichroism Sensing of Chiral Compounds Using an Achiral Metal Complex as Probe
Irfanoglu, B.; Wolf, C.
Chirality 2014, 26, 379-384.

113)    Catalytic Enantioselective Nucleophilic Addition of Ynamides to Aldehydes
Cook, A. M.; Wolf, C.
Chem. Commun. 2014, 50, 3151-3154.

112)    Enantiodifferentiation of Multifunctional Tertiary Alcohols by NMR Spectroscopy with a Whelk-O Type Chiral Solvating Agent
Wolf, C.; Cook, A. M.; Dannatt, J. E.
Tetrahedron: Asymm. 2014, 25, 163-169.

111)    Chirality Sensing of Amines, Diamines, Amino Acids, Amino Alcohols, and α-Hydroxy Acids with a Single Probe
Bentley, K. W., Nam, Y. G.; Murphy, J. M.; Wolf, C.
J. Am. Chem. Soc. 2013, 135, 18052-18055.

110)    A Stereodynamic Chemosensor with Selective Circular Dichroism and Fluorescence Readout for In Situ Determination of Absolute Configuration, Enantiomeric Excess and Concentration of Chiral Compounds
Bentley, K. W., Wolf, C.
J. Am. Chem. Soc. 2013, 135, 12200-12203.

109)    Sensing of the Concentration and Enantiomeric Excess of Chiral Compounds with Tropos Ligand Derived Metal Complexes
Zhang, P.; Wolf, C.
Chem. Commun. 2013, 49, 7010-7012.
Featured in Chemistryworld on July 16, 2013.

108)    Catalytic Enantioselective Difluoroalkylation of Aldehydes
Zhang, P.; Wolf, C.
Angew. Chem. Int. Ed. 2013, 52, 7869-7873.
Featured as a Highlight in Current Synthetic Organic Chemistry in Synfacts 2013, 1084.

107)    Chirality Sensing Using Stereodynamic Probes with Distinct Electronic Circular Dichroism Output
Wolf, C.; Bentley, K. W.
Chem. Soc. Rev. 2013, 42, 5408-5424.

106)    Chiroptical Sensing of Citronellal: Systematic Development of a Stereodynamic Probe Using the Concept of Isostericity
Iwaniuk, D. P.; Wolf, C.
Chem. Commun. 2012, 48, 11226-11228.

105)    Synthesis of Pentafluorinated α-Hydroxy Ketones
Zhang, P.; Wolf, C.
J. Org. Chem. 2012, 77, 8840-8844.
Featured as a Highlight in Current Synthetic Organic Chemistry in Synfacts 2013, 89.

104)    Enantioselective Sensing of Chiral Amino Alcohols with a Stereodynamic Arylacetylene-Based Probe
Iwaniuk, D. P.; Bentley, K. W.; Wolf, C.
Chirality 2012, 24, 584-589.

103)    Stereoselective UV Sensing of 1,2-Diaminocyclohexane Isomers Based on Ligand Displacement with a Diacridylnaphthalene N,N’-Dioxide Scandium Complex
Iwaniuk, D. P.; Yearick-Spangler, K.; Wolf, C.
J. Org. Chem. 2012, 77, 5203-5208.

102)    Copper-Catalyzed C-N Bond Formation with N-Heterocycles and Aryl Halides
Boswell, M. G.; Yeung, F. G.; Wolf, C.
Synlett 2012, 1240-1244.

101)    N-Naphthyl Peptoid Foldamers Exhibiting Atropisomerism
Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Huang, M. L.; Bonneau, R.; Wolf, C.; Kirshenbaum, K.
Org. Lett. 2012, 14, 926-929.

100)    Asymmetric Synthesis of Chiral 1,3-Diaminopropanols via Bisoxazolidine-Catalyzed C-C Bond Formation with α-Keto Amides
Xu, H.; Wolf, C.
Angew. Chem. Int. Ed. 2011, 50, 12249-12252.

99)    Book Review of Signposts to Chiral Drugs: Organic Synthesis in Action
Wolf, C.
J. Am. Chem. Soc. 2011, 133, 16709.

98)    Enantioselective Recognition of Amines with an Atropisomeric 1,8-Bisphenolnaphthalene
Ghosn, M. W.; Wolf, C.
Tetrahedron 2011, 67, 6799-6803.

97)    Peptoid Atropisomers
Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Renfrew, P. D.; Yeung, F. G.; Shah, N. H.; Wolf, C.; Bonneau, R.; Kirshenbaum, K.
J. Am. Chem. Soc. 2011, 133, 10910-10919.

96)    Enantioselective Sensing of Amines Based on [1+1]-, [2+2]-, and [1+2]-Condensation with Fluxional Arylacetylene-Derived Dialdehydes
Iwaniuk, D. P.; Wolf, C.
Org. Lett. 2011, 13, 2602-2605.

95)    Bisoxazolidine-Catalyzed Enantioselective Reformatsky Reaction
Wolf, C.; Moskowitz, M.
J. Org. Chem. 2011, 76, 6372-6376.

94)    Synthesis, Conformational Stability and Asymmetric Transformation of Atropisomeric 1,8-Bisphenolnaphthalenes
Ghosn, M. W.; Wolf, C.
J. Org. Chem. 2011, 76, 3888-3897.

93)    A Stereodynamic Probe Providing a Chiroptical Response to Substrate Controlled Induction of an Axially Chiral Arylacetylene Framework
Iwaniuk, D. P.; Wolf, C.
J. Am. Chem. Soc. 2011, 133, 2414-2417.
Featured as a Highlight in Current Synthetic Organic Chemistry in Synfacts 2011, 493.

92)    Asymmetric Friedel-Crafts Reaction of Indoles with Ethyl Trifluoropyruvate Using a Copper(I)-Bisoxazolidine Catalyst
Zhang, P.; Wolf, C.
Adv. Synth. Catal. 2011, 353, 760-766.
Featured as a Highlight in Current Synthetic Organic Chemistry: Synfacts 2011, 3, 643.

91)    Asymmetric Catalysis with Oxazolidine Ligands
Xu, H.; Wolf, C.
Chem. Commun. 2011, 47, 3339-3350. (Invited review)

90)     Enantioselective Nitroaldol Reaction of α-Ketoesters Catalyzed by a Cu(II)-Bisoxazolidine Complex
Xu, H.; Wolf, C.
Synlett 2010, 2765-2770.

89)    Synthesis of Chiral Tertiary Trifluoromethyl Alcohols by Asymmetric Nitroaldol Reaction with a Cu(II)-Bisoxazolidine Catalyst
Xu, H.; Wolf, C.
Chem. Commun. 2010, 8026-8028.
Featured as a Highlight in Current Synthetic Organic Chemistry: Synfacts 2011, 3, 281.

88)    Stereocontrolled Photodimerization with Congested 1,8-Bis(4’-anilino)naphthalene Templates
Ghosn, M. W.; Wolf, C.
J. Org. Chem. 2010, 75, 6653-6659.

87)    A Versatile and Practical Solvating Agent for Enantioselective Recognition and NMR Analysis of Protected Amines
Iwaniuk, D. P.; Wolf, C.
J. Org. Chem. 2010, 75, 6724-6727.

86)    Enantioselective CD Analysis of Amino Acids Based on Chiral Amplification with a Stereodynamic Probe
Ghosn, M. W.; Wolf, C.
Tetrahedron 2010, 66, 3989-3994.

85)    Metal-free One-pot Oxidative Amination of Aromatic Aldehydes: Conversion of Benzaldehyde to N-Benzoyl Pyrrolidine
Ekoue-Kovi, K.; Wolf, C.
Org. Synth. 2010, 87, 1-7. (invited paper)

84)     Chiral Amplification with a Stereodynamic Triaryl Probe: Assignment of the Absolute Configuration and Enantiomeric Excess of Amino Alcohols
Ghosn, M. W.; Wolf, C.
J. Am. Chem. Soc. 2009, 131, 16360-16361.
Special feature issue in JACS Select: J. Am. Chem. Soc. 2010, 132, 15833.

83)     Asymmetric Copper(I) Catalyzed Henry Reaction with an Aminoindanol-derived Bisoxazolidine Ligand
Yearick Spangler, K.; Wolf, C.
Org. Lett. 2009, 11, 4724-4727.

82)     Chloroquine Transport in Plasmodium falciparum. 1. Influx and Efflux Kinetics for Live Trophozoite Parasites Using a Novel Fluorescent Chloroquine Probe
Cabrera, M.; Natarajan, J. K.; Paguio, M. F.; Wolf, C.; Urbach, J. S.; Roepe, P. D.
Biochemistry 2009, 48, 9471-9481.

81)     Synthesis and Antimalarial Activity of New Chloroquine Analogues Carrying a Multifunctional Linear Side Chain
Iwaniuk, D. P.; Whetmore, E. D.; Rosa, N.; Ekoue-Kovi, K.; Alumasa, J.; de Dios, A. C.; Roepe, P. D.; Wolf, C.
Bioorg. Med. Chem. 2009, 17, 6560-6566.

80)     Copper(I)-catalyzed Amination of Aryl Halides with Aqueous Ammonia
Xu, H.; Wolf, C.
Chem. Commun. 2009, 3035-3037.
This paper was featured in SYNFACTS for its important insights (Synfacts 2009, 893). The aim of SYNFACTS is to inform, on a monthly basis and in a concise manner, of the most significant recent developments and future trends in synthetic chemistry.

79)     Antimalarial Drugs and Heme in Detergent Micelles: An NMR Study
Casabianca, L. B.; Kallgren, J. B.; Natarajan, J. K.; Alumasa, J. N.; Roepe, P. D.; Wolf, C.; de Dios, A. C.
J. Inorg. Biochem. 2009, 103, 745-748.

78)     Copper(I)-catalyzed Coupling of Aryl chlorides, Bromides and Iodides with Amines and Amides
Xu, H.; Wolf, C.
Chem. Commun. 2009, 1715-1719.
This paper was featured by the RSC as a Hot Article.

77)     Synthesis and Antimalarial Activity of New 4-Amino-7-chloroquinolyl Amides, Sulfonamides, Ureas and Thioureas
Ekoue-Kovi, K.; Yearick, K.; Iwaniuk, D. P.; Natarajan, J. K.; Alumasa, J.; de Dios, A. C.; Roepe, P. D.; Wolf, C.
Bioorg. Med. Chem. 2009, 17, 270-283.

76)     Photoaffinity Labeling of the Plasmodium falciparum Chloroquine Resistance Transporter with a Novel Perfluorophenylazido Chloroquine
Lekostaj, J. K.; Natarajan, J. K.; Paguio, M. F.; Wolf, C.; Roepe, P. D.
Biochemistry 2008, 47, 10394–10406.

75)     Palladium-Phosphinous Acid-Catalyzed Cross-Coupling of Aryl and Acyl Halides with Aryl-, Alkyl-, and Vinylzinc Reagents
Xu, H.; Ekoue-Kovi, K.; Wolf, C.
J. Org. Chem. 2008, 73, 7638-7650.

74)     Palladium-phosphinous Acid-catalyzed Cross-coupling of Aliphatic and Aromatic Acyl Chlorides with Boronic Acids
Ekoue-Kovi, K.; Xu, H.; Wolf, C.
Tetrahedron Lett. 2008, 49, 5773-5776.

73)     One-pot Oxidative Esterification and Amidation of Aldehydes
Ekoue-Kovi, K.; Wolf, C.
Chem. Eur. J. 2008, 14, 6302-6315 (Invited review).

72)     Enantioselective Fluorescence Sensing of Chiral α-Amino Alcohols
Liu, S.; Pestano, J. P. C.; Wolf, C.
J. Org. Chem. 2008, 73, 4267-4270.

71)     Quinine and Chloroquine Differentially Perturb Heme Monomer-Dimer Equilibrium
Casabianca, L. B.; An, D.; Natarajan, J. K.; Alumasa, J. N.; Roepe, P. D.; Wolf, C.; de Dios, A. C.
Inorg. Chem. 2008, 47, 6077-6081.  

70)     Catalytic Enantioselective Addition of Diethylzinc to Trifluoromethyl Ketones
Yearick, K.; Wolf, C.
Org. Lett. 2008, 10, 3915-3918.

69)     4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs Chloroquine Resistant Malaria
Natarajan, J. K.; Alumasa, J. N.; Yearick, K.; Ekoue-Kovi, K. A.; Casabianca, L. B.; de Dios, A. C.; Wolf, C.; Roepe, P. D.
J. Med. Chem. 2008, 51, 3466-3479.

68)     Overcoming Drug Resistance to Heme-targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines
Yearick, K.; Ekoue-Kovi, K.; Iwaniuk, D. P.; Natarajan, J. K.; Alumasa, J.; de Dios, A. C.; Roepe, P. D.; Wolf, C.
J. Med. Chem. 2008, 51, 1995-1998.

67)     Asymmetric Nitroaldol Reaction Catalyzed by a C2-Symmetric Bisoxazolidine Ligand
Liu, S.; Wolf, C.
Org. Lett. 2008, 10, 1831-1834.
This paper was featured in SYNFACTS for its important insights (Synfacts 2008, 715).

66)    Efficient Synthesis of Sterically Crowded Biaryls by Palladium-Phosphinous Acid-catalyzed Cross-Coupling of Aryl Halides and Aryl Grignards
Wolf, C.; Xu, H.
J. Org. Chem. 2008, 73, 162-167.
This paper was featured in SYNFACTS for its important insights (Synfacts 2008, 1315). The aim of SYNFACTS is to inform, on a monthly basis and in a concise manner, of the most significant recent developments and future trends in synthetic chemistry.

65)     Chiral Amplification Based on Enantioselective Dual Phase Distribution of a Scalemic Bisoxazolidine Catalyst
Liu, S.; Wolf, C.
Org. Lett. 2007, 9, 2965-2968.

64)     Palladium(II)-Catalyzed Conjugate Addition of Arylsiloxanes in Water
Lerebours, R.; Wolf, C.
Org. Lett. 2007, 9, 2737-2740.

63)     Metal-Free One-Pot Oxidative Amination of Aldehydes to Amides
Ekoue-Kovi, K.; Wolf, C.
Org. Lett. 2007, 9, 3429-3432.

62)     Template-controlled Face-to-Face Stacking of Olefinic and Aromatic Carboxylic Acids in the Solid State
Mei, X.; Liu, S.; Wolf, C.
Org. Lett. 2007, 9, 2729-2732.

61)     Analysis of the Stereodynamics of 2,2’-Disubstituted Biphenyls by Dynamic Chromatography
Wolf, C.; Xu, H.
Tetrahedron Lett. 2007, 48, 6886-6889.

60)    Regioselective Copper-Catalyzed C-N and C-S Bond Formation using Amines, Thiols and Halobenzoic Acids
Liu, S.; Pestano, J. P. C.; Wolf, C.
Synthesis 2007, 3519-3527.

59)    Determination of Enantiomeric Excess and Concentration of Unprotected Amino Acids, Amines, Amino Alcohols, and Carboxylic Acids by Competitive Binding Assays with a Chiral Scandium Complex
Mei, X.; Wolf, C.
J. Am. Chem. Soc. 2006, 128, 13326-13327.

58)    An Enantioselective Fluorescence Sensing Assay for Quantitative Analysis of Chiral Carboxylic Acids and Amino Acid Derivatives
Wolf, C.; Liu, S.; Reinhardt, B. C.
Chem. Commun. 2006, 4242-4244.

57)    Chemoselective Nucleophilic Arylation and Single-Step Oxidative Esterification of Aldehydes Using Siloxanes and a Palladium-phosphinous Acid as a Reaction Switch
Lerebours, R.; Wolf, C.
J. Am. Chem. Soc. 2006, 128, 13052-13053.

56)    Determination of Enantiomeric Excess and Concentration of Chiral Compounds Using a 1,8-Diheteroarylnaphthalene-Derived Fluorosensor
Mei, X.; Wolf, C.
Tetrahedron Lett. 2006, 47, 7901-7904.

55)    Bisoxazolidine-Catalyzed Enantioselective Alkynylation of Aldehydes
Wolf, C.; Liu, S.
J. Am. Chem. Soc. 2006, 128, 10996-10997.

54)    Conformational Polymorphism of 1,8-Dipyridylnaphthalene and Encapsulation of Chains of Fused Cyclic Water Pentamers in a Hydrophobic Crystal Environment
Mei, X.; Wolf, C.
CrystEngComm 2006, 8, 377-380.

53)    Synthesis of a Sterically Crowded Atropisomeric 1,8-Diacridylnaphthalene for Dual Mode Enantioselective Fluorosensing
Mei, X.; Martin, R. M.; Wolf, C.
J. Org. Chem. 2006, 71, 2854-2861.

52)    Regioselective Copper-Catalyzed Amination of Bromobenzoic Acids Using Aliphatic and Aromatic Amines
Wolf, C.; Liu, S.; Mei, X.; August, A. T.; Casimir, M. D.
J. Org. Chem. 2006, 71, 3270-3273.

51)    Regioselective Copper-Catalyzed Amination of Chlorobenzoic Acids: Synthesis and Solid-State Structures of N-Aryl Anthranilic Acids
Mei, X.; August, A. T.; Wolf, C.
J. Org. Chem. 2006, 71, 142-149.

50)    Palladium-catalyzed Suzuki-Miyaura Cross-Coupling Using Phosphinous Acids and Dialkylchlorophosphine Ligands
Wolf, C.; Ekoue-Kovi, K.
Eur. J. Org. Chem. 2006, 1917-1925.

49)    Palladium-Catalyzed Chemoselective Cross-Coupling of Acyl Chlorides and Organostannanes
Lerebours, R.; Camacho-Soto, A.; Wolf, C.
J. Org. Chem. 2005, 70, 8601-8604.

48)    Enantioselective Analysis of an Asymmetric Reaction Using a Chiral Fluorosensor
Tumambac, G. E.; Wolf, C.
Org. Lett. 2005, 7, 4045-4048.

47)    Crystallization through Slow Acid-Controlled Hydrolytic Release of a Highly Polar Organic Compound: Formation of a Dipolar Acridone Polymorph
Mei, X.; Wolf, C.
Cryst. Growth Des. 2005, 5, 1667-1670.

46)    Palladium-Phosphinous Acid Catalyzed Cross-Coupling of Aryl Halides Using a Hypervalent Phenylsilane in Water
Lerebours, R.; Wolf, C.
Synthesis 2005, 2287-2292.

45)    Stereolabile Chiral Compounds: Analysis by Dynamic Chromatography and Stopped-Flow Methods
Wolf, C.
Chem. Soc. Rev. 2005, 34, 595-608. (Invited tutorial)

44)    Synthesis and Stereodynamics of Highly Constrained 1,8-Bis(2,2’-dialkyl-4,4’-diquinolyl)naphthalenes (2)
Tumambac, G. E.; Wolf, C.
J. Org. Chem. 2005, 70, 2930-2938.

43)    Highly Congested Nondistorted Diheteroarylnaphthalenes: Model Compounds for the Investigation of Intramolecular -Stacking Interactions
Mei, X.; Wolf, C.
J. Org. Chem. 2005, 70, 2299-2305.

42)    Configurational Stability of 2-Benzoylcyclohexanone: Unexpected Solvent Effects on the Rate of Racemization
Tumambac, G. E.; Francis, C. J.; Wolf, C.
Chirality 2005, 17, 171-176.

41)    Elucidation of the Presence and Location of t-Boc Protecting Groups in Amines and Dipeptides Using On-Column H/D Exchange HPLC/ESI/MS
Wolf, C.; Villalobos, C. N.; Cummings, P. G.; Kennedy-Gabb, S.; Olsen, M. A.;
Trescher, G.
J. Am. Soc. Mass Spectrom. 2005, 16, 553-564.

40)    Neutral and Ionic Supramolecular Structures of Unsaturated Dicarboxylic Acids and Acridine: Significance of Molecular Geometry and Proton Transfer
Mei, X.; Wolf, C.
Eur. J. Org. Chem. 2004, 4340-4347.

39)    A Highly Congested N,N’-Dioxide Fluorosensor for Enantioselective Recognition of Chiral Hydrogen Bond Donors
Mei, X.; Wolf, C.
Chem. Commun. 2004, 2078-2079.

38)    Formation of New Polymorphs of Acridine Using Dicarboxylic Acids as Crystallization Templates in Solution
Mei, X.; Wolf, C.
Cryst. Growth Des. 2004, 4, 1099-1103.

37)    Selective Detection of Fe(III) Ions in Aqueous Solution with a 1,8-Diacridylnaphthalene-Derived Fluorosensor
Wolf, C.; Mei, X.; Rokadia, H.
Tetrahedron Lett. 2004, 45, 7867-7871.

36)    Stereoselective Sensing by Substrate-Controlled syn/anti-Interconversion of a Stereodynamic Sensor
Tumambac, G. E.; Mei, X.; Wolf, C.
Eur. J. Org. Chem. 2004, 3850-3856.

35)    Palladium Phosphinous Acid-Catalyzed NaOH-promoted Cross-Coupling Reactions of Arylsiloxanes with Aryl Chlorides and Bromides in Water
Wolf, C.; Lerebours, R.
Org. Lett. 2004, 6, 1147-1151.

34)    Enantioselective Sensing of Chiral Carboxylic Acids
Mei, X.; Wolf, C.
J. Am. Chem. Soc. 2004, 126, 14736-14737.

33)    Synthesis and Stereodynamics of Highly Constrained 1,8-Bis(2,2’-dialkyl-4,4’-diquinolyl)naphthalenes
Wolf, C.; Tumambac, G. E.
J. Org. Chem. 2004, 69, 2048-2055.

32)    Palladium-Phosphinous Acid-Catalyzed Sonogashira Cross-Coupling Reactions in Water
Wolf, C.; Lerebours, R.
Org. Biomol. Chem. 2004, 2, 2161-2164.

31)    Chiral Dihydropyranones via Hetero-Diels-Alder Reaction of Danishefsky’s Diene and α-Ketoesters: a High-Throughput Screening Approach
Wolf. C.; Fadul, Z.; Hawes, P. A.; Volpe, E. C.
Tetrahedron: Asymm. 2004, 15, 1987-1993.

30)    Selective Metal Ion Recognition Using a Fluorescent 1,8-Diquinolylnaphthalene-Derived Sensor in Aqueous Solution
Tumambac, G. E.; Rosencrance, C.; Wolf, C.
Tetrahedron, 2004, 60, 11293-11297.

29)    Use of Highly Active Palladium-Phosphinous Acid Catalysts in Stille, Heck, Amination, and Thiation Reactions of Chloroquinolines
Wolf, C.; Lerebours, R.
J. Org. Chem. 2003, 68, 7077-7084.

28)    Cross-Coupling Reactions of Aryl Chlorides and Bromides with Phenyltrimethoxysilane Catalyzed by Palladium-Phosphinous Acid Complexes
Wolf, C.; Lerebours, R.; Tanzini, E. H.
Synthesis 2003, 2069-2073.

27)    Efficient Stille Cross-Coupling Reaction Using Aryl Chlorides or Bromides in Water
Wolf, C.; Lerebours, R.
J. Org. Chem. 2003, 68, 7551-7554.

26)    Acid-mediated Halogen Exchange in Heterocyclic Arenes. A Highly Effective Iodination Method
Wolf, C.; Tumambac, G. E.; Villalobos, C. N.
Synlett 2003, 1801-1804.

25)    Synthesis of Conformationally Stable 1,8-Diarylnaphthalenes: Development of New Photoluminescent Sensors for Ion-Selective Recognition
Wolf, C.; Mei, X.
J. Am. Chem. Soc. 2003, 125, 10651-10658.

24)    Investigation of the Stereodynamics of Axially Chiral 1,8-Bis(2,2’-diphenyl-4,4’-dipyridyl)naphthalene and Cryogenic Separation of Its syn/anti-Isomers
Wolf, C.; Tumambac, G. E.
J. Phys. Chem. A 2003, 107, 815-817.

23)    A Convenient Method for the Determination of the Absolute Configuration of Chiral Amines
Wolf, C.; Pranatharthiharan, L.; Volpe, E. C.
J. Org. Chem. 2003, 68, 3287-3290.

22)    A High-Throughput Screening Protocol for Fast Evaluation of Enantioselective Catalysts
Wolf, C.; Hawes, P. A.
J. Org. Chem. 2002, 67, 2727-2729.

21)    Synthesis of Atropisomeric 1,8-Bis(4’,4’-dipyridyl)naphthalenes from 4-Trimethylstannylpyridines
Wolf, C.; Ghebremariam, B. T.
Synthesis 2002, 749-752.

20)    Conformational Effects on the Enantioselective Recognition of 4-(3,5-Dinitrobenzamido)-1,2,3,4-tetrahydrophenanthrene Derivatives by a Naproxen-Derived Chiral Stationary Phase
Wolf, C.; Pirkle, W. H.
Tetrahedron 2002, 58, 3597-3603.

19)    Dynamic Stereochemistry of 1,8-Bis(2,2’-disubstituted-4,4’-dipyridyl)naphthalenes and Their N,N’-Dioxide Derivatives
Wolf, C.; Ghebremariam, B. T.
Tetrahedron: Asymm. 2002, 13, 1153-1156.

18)    Enantioselective Alkylation of Aldehydes Using (S)-Tyrosine-Derived a-Amino Alcohols
Wolf, C.; Francis, C. J.; Hawes, P. A.; Shah, M.
Tetrahedron: Asymm. 2002, 13, 1733-1741.

17)    Conformational Stability of Atropisomeric 1-Naphthylcarbinols and 1-(1-Naphthyl)ethylamines
Wolf, C.; Pranatharthiharan, L.; Ramagosa, R. B.
Tetrahedron Lett. 2002, 43, 8563-8567.

16)    Investigation of Capillary Electrochromatography with Brush-Type Chiral Stationary Phases
Wolf, C.; Spence, P. L.; Pirkle, W. H.; Cavender, D. M.; Derrico, E. M.
Electrophoresis 2000, 21, 917-924.

15)    Synthesis and Evaluation of a Copolymeric Chiral Stationary Phase
Wolf, C.; Pirkle, W. H.
J. Chromatogr. A 1998, 799, 177-184.

14)    Enantioseparations by Electrochromatography with Packed Capillaries
Wolf, C.; Spence, P. L.; Pirkle, W. H.; Derrico, E. M.; Cavender, D. M.;
Rozing, G. P.
J. Chromatogr. A 1998, 782, 175-179.

13)    Determination of the Energy Barriers of Arylnaphthalene Lignans by Cryogenic Subcritical Fluid Chromatography and Computer Simulation
Wolf, C.; Pirkle, W. H.; Welch, C. J.; Hochmuth, D. H.; König, W. A.; Chee, G.-L.; Charlton, J. L.
J. Org. Chem. 1997, 62, 5208-5210.

12)    Enantioseparations by Subcritical Fluid Chromatography at Cryogenic Temperatures
Wolf, C.; Pirkle, W. H.
J. Chromatogr. A 1997, 785, 173-178.

11)    Enantiomer Separation by Supercritical Fluid Chromatography on Packed Columns
Wolf, C.; Pirkle, W. H.
LC-GC 1997, 15, 352-363.

10)    1,2,3-Trithiane-5-carboxylic Acid, a First Contact Allergen From Asparagus Officinalis (Liliaceae)
Hausen, B. M.; Wolf, C.
American Journal of Dermatitis 1996, 7, 41-46.

9)    New Technique for the Determination of Interconversion Processes Based on Capillary Zone Electrophoresis: Studies With Axially Chiral Biphenyls
Weseloh, G.; Wolf, C.; König, W. A.
Chirality 1996, 8, 441-445.

8)    Influence of Substituents on the Rotational Energy Barrier of Axially Chiral Biphenyls, II
Wolf, C.; Hochmuth, D. H.; König, W. A.; Roussel, C.
Liebigs Ann. Chem. 1996 357-363.

7)    Conversion of a Racemate into a Single Enantiomer in One Step by Chiral Liquid Chromatography: Studies with rac-2,2’-Diiodobiphenyl
Wolf, C.; König, W. A.; Roussel, C.
Chirality 1995, 7, 610-611.

6)    A New Application of Capillary Zone Electrophoresis: Determination of Energy Barriers of Configurationally Labile Chiral Compounds
Weseloh, G.; Wolf, C.; König, W. A.
Angew. Chem. Int. Ed. Engl. 1995, 34, 1635-1636.

5)    Influence of Substituents on the Rotational Energy Barrier of Atropisomeric Biphenyls - Studies by Polarimetry and Dynamic Gas Chromatography
Wolf, C.; König, W. A.; Roussel, C.
Liebigs Ann. Chem. 1995, 781-786.

4)    Gas Chromatographic Enantiomer Separation of Agrochemicals and Polychlorinated Biphenyls (PCBs) Using Modified Cyclodextrins
Hardt, I. H.; Wolf, C.; Gehrcke, B.; Hochmuth, D. H.; Pfaffenberger, B.; Hühnerfuss, H.; König, W. A.
J. High Res. Chromatogr. 1994, 17, 859-864.

3)    Gas Chromatographic Separation of Atropisomeric Alkylated and Polychlorinated Biphenyls Using Modified Cyclodextrins
König, W. A.; Gehrcke, B.; Runge, T.; Wolf, C.
J. High Res. Chromatogr. 1993, 16, 376-378.

2)    Some Striking Rate and Migration Effects of Trimethylsilyl Substituents on Cyclopropene Isomerisation
Walsh, R.; Wolf, C.; Untiedt, S.; de Meijere, A.
J. Chem. Soc., Chem. Commun. 1992, 422-424.

1)    The Kinetics of Pyrolysis of 1,3,3-Trimethylcyclopropene. Evidence for the Involvement of Alkylidene Carbenes in the Thermal Isomerisation of Cyclopropenes
Walsh, R.; Wolf, C.; Untiedt, S.; de Meijere, A.
J. Chem. Soc., Chem. Commun. 1992, 421-422.
 

PATENTS
 

8) Quantitative Chirality and Concentration Sensing of Chiral Analytes Using a Relay Assay
Inventors: Wolf, C.;Thanzeel, F. Y.; Balaraman, K.
WO2021/225688 AI

​

7) Determining Stereoisomeric Excess and/or Concentration and/or Absolute Configuration of Chiral Compounds In a Sample
Inventors: Wolf, C.; Zhang, P.; Bentley, K. W.; Irfanoglu, B.
U.S. Patent 10,900,941

6) Determining Stereoisomeric Excess, Concentration and Absolute Configuration
Inventors: Wolf, C.; Zhang, P.
US Patent 10,012,627

5) Stereodynamic Chemosensors
Inventors: Wolf, C.; Bentley, K. W.
US Patent 9,815,746

4) Atropisomeric 1,8-Bisphenolnaphthalenes and Their Use in Enantioselective Recognition and Asymmetric Synthesis
Inventors: Wolf, C.; Ghosn, M. W.
US Patent 9,085,511

3) Compositions and Methods for the Treating for Giardiasis
Inventors: Elmendorf, H. G.; Walls, C. D.; Wolf, C.
US Patent 8,779,202

2) Synthesis, Structure and Use of Bisoxazolidines for Asymmetric Catalysis and Synthesis
Inventors: Christian Wolf, Shuanglong Liu
U.S. Patent 7,763,734
Licensed to Strem Chemicals, Inc., Wolf Bisoxazolidine, Catalogue # 07-0488

1) Chiral 1,8-Diarylnaphthalenes, Methods of Making Them, and Their Use as Sensors
Inventors: Christian Wolf, Xuefeng Mei
U.S. Patent 7,888,509